TPDB63421

FITC-Acp-(PRR)5 Cell-penetrating Peptides modified_plain modified

15 amino acids

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63421

Peptide_Name

FITC-Acp-(PRR)5

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 15-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

N-terminal: Extended with 6-Aminohexanoic Acid (Acp)

Sequence

PRRPRRPRRPRRPRR

FASTA

>TPDB63421|Cell-penetrating Peptides|length=15
PRRPRRPRRPRRPRR

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

15 reviewed residue count

C_terminal_Modification

Free Activity

Chirality

L Activity

Linearity

Linear Activity

N_terminal_Modification

Extended with 6-Aminohexanoic Acid (Acp) Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Bv2 And U87 Cells

Assay & Model

In Vitro Model Male mice (Kunming strain of Swiss, weighing 20−22 g, 8−10 weeks-old)

In Vivo Model Male mice (Kunming strain of Swiss, weighing 20−22 g, 8−10 weeks-old)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Non-natural residues Linear L

Source of Peptide Synthetic

Cargo Type FITC dye and Rho-labelled MOTS-c peptide

Uptake Efficiency Transmembrane ability of (PRR)5 was superior to that of other CPPs

In Vitro or In Vivo In vitro and in vivo