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Peptide record

TPDB63409

1746c27 Cell-penetrating Peptides standard
47 amino acids
Basic Information
3D PDB MODEL
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TPDB63409
1746c27
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 47-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
PPHPRPLPAPAQSRKKQKGRAGRGHEKTGASVLRGPQKPHPLPAQLR
Physicochemical Analysis
C223H374N80O57
NDCIMFWY
P
5087.92
12.71
14
1
10
+10
18.96
-1.394
50.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
7
Residue Composition
number
5
A
6
R
0
N
0
D
0
C
1
E
4
Q
5
G
3
H
0
I
4
L
5
K
0
M
0
F
10
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 6 N: 0 D: 0 C: 0 E: 1 Q: 4 G: 5 H: 3 I: 0 L: 4 K: 5 M: 0 F: 0 P: 10 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
47
C223H374N80O57
5087.92
12.71
+10
18.96
-1.394
Free
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293, A431, CHO-K1 , Hl-60, Amo-1, T47D

Assay & Model

C57BL/10ScSnmdx mice (initially at 3–5 days of age)
C57BL/10ScSnmdx mice (initially at 3–5 days of age)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Proapoptotic peptide PAP , DPMIα peptide , β-lactamase , Omomyc protein, Affibody_Bouganin cargo and PMO-M23D(+7–18)
Cytoplasm
Dose-dependent uptake
In vitro and in vivo
CCCCCCCCCCCTTCCCCCSSSSCTTSCGGGGCCSSSSSCSSCCSSSCCCTTSSSCSCC
Additional Detail Fields 1 fields
CCCCCCCCCCCTTCCCCCSSSSCTTSCGGGGCCSSSSSCSSCCSSSCCCTTSSSCSCC