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Peptide record

TPDB63399

Cell-penetrating Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB63399
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 37-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: EBD_S11 fusion proteins
Sequence
PNDKSGNDIANCLRKNGKRVVQLSRKTFDTEYQKTKS
Physicochemical Analysis
C179H300N58O59S1
HMW
K
4240.76
10.35
9
4
8
+5
14.43
-1.419
50.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
35.14
14
Residue Composition
number
1
A
3
R
4
N
3
D
1
C
1
E
2
Q
2
G
0
H
1
I
2
L
6
K
0
M
1
F
1
P
3
S
3
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 4 D: 3 C: 1 E: 1 Q: 2 G: 2 H: 0 I: 1 L: 2 K: 6 M: 0 F: 1 P: 1 S: 3 T: 3 W: 0 Y: 1 V: 2
Chemical Descriptors
37
C179H300N58O59S1
4240.76
10.35
+5
14.43
-1.419
Free
EBD_S11 fusion proteins
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcc-827, Hek-293 , A431, CHO-K1 , Hl-60, Amo-1, T47D Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
GFP1–10 plasmid
Cytoplasm
Dose-dependent uptake
In vitro
CCCCCGGGTCCCCSSSCTTTSCCCCHHHHHHTC
Additional Detail Fields 1 fields
CCCCCGGGTCCCCSSSCTTTSCCCCHHHHHHTC