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Peptide record

TPDB63394

WTAS Cell-penetrating Peptides modified_plain modified
27 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63394
WTAS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 27-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: poly(β-amino ester) (PBAE) polymer
Sequence
PLKWPGKKKKGKPGKRKEQEKKKRRTR
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
27 reviewed residue count
Free Activity
poly(β-amino ester) (PBAE) polymer Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16F10 Cell Line, Nscs,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
GFP plasmid DNA and rhodamine B
Nucleus
WTAS was able to penetrate NSCs cell line, but it was not able to be further taken into the cell nuclei as it did in B16F10 cells
In vitro
CCSSSCC
Additional Detail Fields 1 fields
CCSSSCC