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Peptide record

TPDB63394

WTAS Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB63394
WTAS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: poly(β-amino ester) (PBAE) polymer
Sequence
PLKWPGKKKKGKPGKRKEQEKKKRRTR
Physicochemical Analysis
C147H262N52O34
ANDCHIMFSYV
K
3302.03
12.08
15
2
2
+13
17.86
-2.785
14.44
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
5500
166.56
2
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
2
E
1
Q
3
G
0
H
0
I
1
L
11
K
0
M
0
F
3
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 3 H: 0 I: 0 L: 1 K: 11 M: 0 F: 0 P: 3 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
27
C147H262N52O34
3302.03
12.08
+13
17.86
-2.785
Free
poly(β-amino ester) (PBAE) polymer
L
Linear
Free
N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16F10 Cell Line, Nscs,

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
GFP plasmid DNA and rhodamine B
Nucleus
WTAS was able to penetrate NSCs cell line, but it was not able to be further taken into the cell nuclei as it did in B16F10 cells
In vitro
CCSSSCC
Additional Detail Fields 1 fields
CCSSSCC