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Peptide record

TPDB63392

Cell-penetrating Peptides standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB63392
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 38-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: EBD_S11 fusion proteins
Sequence
PLKPKKPKTQEKKKKQPPKPKKPKTQEKKKKQPPKPKR
Physicochemical Analysis
C208H371N63O49
ANDCGHIMFSWYV
K
4538.63
11.39
19
2
1
+17
29.21
-2.876
10.26
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
6
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
2
E
4
Q
0
G
0
H
0
I
1
L
18
K
0
M
0
F
10
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 2 Q: 4 G: 0 H: 0 I: 0 L: 1 K: 18 M: 0 F: 0 P: 10 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
38
C208H371N63O49
4538.63
11.39
+17
29.21
-2.876
Free
EBD_S11 fusion proteins
L
Linear
Free
N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcc-827, Hek-293 , A431, CHO-K1 , Hl-60, Amo-1, T47D Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
GFP1–10 plasmid and proapoptotic peptide PAP
Cytoplasm
Dose-dependent uptake
In vitro
CCSCCCCCCSSSSSSSCCC
Additional Detail Fields 1 fields
CCSCCCCCCSSSSSSSCCC