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Peptide record

TPDB63391

TP2 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63391
TP2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Chemical: Nanopaticles
Sequence
PLIYLRLLRGQF
Physicochemical Analysis
C72H117N19O15
ANDCEHKMSTWV
L
1488.84
11.16
2
0
7
+2
-1.96
0.558
162.50
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
100.08
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
1
I
4
L
0
K
0
M
1
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 1 L: 4 K: 0 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
12
C72H117N19O15
1488.84
11.16
+2
-1.96
0.558
Free
Nanopaticles
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells And And Pgsa-745 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
ATTO 425 and Tetramethylrhodamine-5-maleimide (TAMRA)
Cytoplasm
No direct translocation was observed for both TP2-ATTO and TP2-TAMRA even below the CMC value, only punctuate fluorescence staining was detected within live cells
Endocytosis
In vitro
CCSCCCSSSCC
Additional Detail Fields 1 fields
CCSCCCSSSCC