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Peptide record

TPDB63388

Cell-penetrating Peptides standard
59 amino acids
Basic Information
3D PDB MODEL
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TPDB63388
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 59-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: EBD_S11 fusion proteins
Sequence
PKQPPKPKKPKTQEKKKKQPAKPKPGKRQRMALKLEADRLFDVKNEDGDVIGHALDMKA
Physicochemical Analysis
C297H506N90O82S2
CSWY
K
6713.96
10.68
19
8
15
+10
32.11
-1.554
51.36
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
6
Residue Composition
number
5
A
3
R
1
N
5
D
0
C
3
E
4
Q
3
G
1
H
1
I
4
L
15
K
2
M
1
F
8
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 3 N: 1 D: 5 C: 0 E: 3 Q: 4 G: 3 H: 1 I: 1 L: 4 K: 15 M: 2 F: 1 P: 8 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
59
C297H506N90O82S2
6713.96
10.68
+10
32.11
-1.554
Free
EBD_S11 fusion proteins
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcc-827, Hek-293 , A431, CHO-K1 , Hl-60, Amo-1, T47D Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
GFP1–10 plasmid
Cytoplasm
Dose-dependent uptake
In vitro
CCCCSSCCSSSCCCCCSCCCCCSSCCSCCCC
Additional Detail Fields 1 fields
CCCCSSCCSSSCCCCCSCCCCCSSCCSCCCC