TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63386

Peptide_Name

H0K

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 7-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acetylation

Sequence

Ac-PKPKRKV-NH2

Source representation

>TPDB63386|Cell-penetrating Peptides|length=7
Ac-PKPKRKV-NH2

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

7 reviewed residue count

C_terminal_Modification

Amidation Activity

Chirality

L Activity

Ionic_State

Amphipathic Activity

Linearity

Linear Activity

N_terminal_Modification

Acetylation Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line A549 Cells

Assay & Model

In Vitro Model A549 tumor bearing xenograft six-week-old male BALB/c nude mice

In Vivo Model A549 tumor bearing xenograft six-week-old male BALB/c nude mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Non-natural residues Linear L Amphipathic

Source of Peptide Synthetic

Cargo Type Cy-3 labeled siRNA

Subcellular Localization Cytosol and around Nucleus

Uptake Efficiency The complexes of Cy-3 labeled siRNA with H0 K or HK exhibited a 15% cellular uptake rate.

Uptake Mechanism Endocytosis

In Vitro or In Vivo In vitro and in vivo