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Peptide record

TPDB63380

NLS Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63380
NLS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with Alkyne Group
Sequence
PKKKRKVKAA
Physicochemical Analysis
C52H100N18O11
NDCEQGHILMFSTWY
K
1153.48
11.85
6
0
3
+6
5.94
-1.780
49.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
0
0.00
0
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
5
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 5 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
10
C52H100N18O11
1153.48
11.85
+6
5.94
-1.780
Conjugated with Alkyne Group
L
Linear
Free
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
CdSe/ZnS quantum dots (QDs)
Nuclei
More than 50% (on average) of QD-NLS were found in the cell nucleus or in close vicinity to it, while less than 15% (on average) for QD-COOH and QD-azide.
Endocytosis
In vitro
CCSGGGCCSCC
Additional Detail Fields 1 fields
CCSGGGCCSCC