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Peptide record

TPDB63370

FGF-12 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63370
FGF-12
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and MLCPP 2.0, with an available 3D structural model.
N-terminal: Fluorescein
Sequence
PIEVCMYREP
Physicochemical Analysis
C54H85N13O16S2
ANDQGHLKFSTW
EP
1236.47
4.26
1
2
4
-1
4.10
-0.290
68.00
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
120.50
2
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
2
E
0
Q
0
G
0
H
1
I
0
L
0
K
1
M
0
F
2
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 2 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 0 M: 1 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
10
C54H85N13O16S2
1236.47
4.26
-1
4.10
-0.290
Free
L
Amphipathic
Linear
Fluorescein
N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

3T3-L1 Adipocytes , (Hmsc)-Derived Adipocytes , (Hmadscs)

Assay & Model

10-week-old female Swiss mice
10-week-old female Swiss mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
Fluorescein via propargylic glycine
Fl-FGF,were efficiently taken up by both 3T3-L1 and stromal vascular fraction (SVF)-derived primary adipocytes
In vitro and in vivo
CCSCC
Additional Detail Fields 1 fields
CCSCC