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Peptide record

TPDB63368

tripartite peptide AntpMAPMUC1tet Cell-penetrating Peptides standard
57 amino acids
Basic Information
3D PDB MODEL
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TPDB63368
tripartite peptide AntpMAPMUC1tet
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 57-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
PGSTAPPAHGVTSAPDTRPAPGSRQIKIWFQNRRMKWKKENKQYIKANSKFIGITEL
Physicochemical Analysis
C289H460N86O79S1
C
K
6435.42
11.21
12
3
18
+8
13.20
-0.935
54.91
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
12490
194.08
15
Residue Composition
number
5
A
4
R
3
N
1
D
0
C
2
E
3
Q
4
G
1
H
5
I
1
L
7
K
1
M
2
F
6
P
4
S
4
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 5 R: 4 N: 3 D: 1 C: 0 E: 2 Q: 3 G: 4 H: 1 I: 5 L: 1 K: 7 M: 1 F: 2 P: 6 S: 4 T: 4 W: 2 Y: 1 V: 1
Chemical Descriptors
57
C289H460N86O79S1
6435.42
11.21
+8
13.20
-0.935
Free
L
Branched
Free
N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC/C=N/C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Bone Marrow Derived Dendritic Cells (Bmdc)

Assay & Model

C57BL/6 and HLA-A2 transgenic mice
C57BL/6 and HLA-A2 transgenic mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Branched L
Fusogenic
Alexa 488-labelled
Cytoplasm
Rapid uptake was observed within 5 min, remaining constant for 60 min
Macropinocytosis or phagocytosis
In vitro and in vivo
CCSSSCSSCCCCCSSSSCCSCCSSCCCCTTTCCHHHHHTTCCCCSCCCCCSSSCCC
Additional Detail Fields 1 fields
CCSSSCSSCCCCCSSSSCCSCCSSCCCCTTTCCHHHHHTTCCCCSCCCCCSSSCCC