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Peptide record

TPDB63367

Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB63367
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: EBD_S11 fusion proteins
Sequence
PGRVGISLKVESVRNKDRKKPYKG
Physicochemical Analysis
C119H207N39O33
ACQHMFTW
K
2712.19
11.09
8
2
6
+6
10.64
-1.246
68.75
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
54.94
4
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
1
E
0
Q
3
G
0
H
1
I
1
L
5
K
0
M
0
F
2
P
2
S
0
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 1 L: 1 K: 5 M: 0 F: 0 P: 2 S: 2 T: 0 W: 0 Y: 1 V: 3
Chemical Descriptors
24
C119H207N39O33
2712.19
11.09
+6
10.64
-1.246
Free
EBD_S11 fusion proteins
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hcc-827, Hek-293 , A431, CHO-K1 , Hl-60, Amo-1, T47D Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
GFP1–10 plasmid
Cytoplasm
Dose-dependent uptake
In vitro
CCSHHHHTTSCCCTTSSCTTTSCCCCCCCCCCCSSCTTSCTTCSSSSSCCCSSCCTTCC
Additional Detail Fields 1 fields
CCSHHHHTTSCCCTTSSCTTTSCCCCCCCCCCCSSCTTSCTTCSSSSSCCCSSCCTTCC