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Peptide record

TPDB63364

FITC-HNLS-3 Cell-penetrating Peptides modified_plain modified
21 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63364
FITC-HNLS-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 21-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
PFVYLIPKKKRKVHHHHHHGK-NH2
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
21 reviewed residue count
Amidation Activity
L Activity
Linear Activity
Free Activity
N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC-conjugated at C terminus
Cytoplasm and nucleus
FITC-HNLS-3 possessed a strong pH-dependent cellular uptake capacity compared with FITC-TAT and FITC-HNLS-2 and showed increased cellular uptake efficiency under acidic conditions pH5.5.
Direct penetration and endocytosis
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC