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Peptide record

TPDB63364

FITC-HNLS-3 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB63364
FITC-HNLS-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
PFVYLIPKKKRKVHHHHHHGK-NH2
Physicochemical Analysis
C124H191N41O23
ANDCEQMSTW
H
2624.14
11.14
12
0
6
+7
9.63
-1.362
64.76
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
56.78
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
6
H
1
I
1
L
5
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 6 I: 1 L: 1 K: 5 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
21
C124H191N41O23
2624.14
11.14
+7
9.63
-1.362
Amidation
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC-conjugated at C terminus
Cytoplasm and nucleus
FITC-HNLS-3 possessed a strong pH-dependent cellular uptake capacity compared with FITC-TAT and FITC-HNLS-2 and showed increased cellular uptake efficiency under acidic conditions pH5.5.
Direct penetration and endocytosis
In vitro
CCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCC