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Peptide record

TPDB63363

HNLS-3–CPT HNLS-3 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB63363
HNLS-3–CPT HNLS-3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
PFVYLIPKKKRKVHHHHHHGC-NH2
Physicochemical Analysis
C121H184N40O23S1
ANDEQMSTW
H
2599.11
10.63
11
0
6
+5
8.40
-1.057
64.76
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1490
57.33
2
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
0
Q
1
G
6
H
1
I
1
L
4
K
0
M
1
F
2
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 6 I: 1 L: 1 K: 4 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
21
C121H184N40O23S1
2599.11
10.63
+5
8.40
-1.057
Amidation
L
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](CS)C(=O)O N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Cytoplasm and nucleus
Highest cellular uptake of HNLS-3 under acidic conditions.
Direct penetration and endocytosis
In vitro
CCCCCSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cell Line

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Camptothecin (CPT)
Cytoplasm and nucleus
Direct penetration and endocytosis
In vitro
CCCCCCCCCCTTCCC
Additional Detail Fields 1 fields
CCCCCSSCC CCCCCCCCCCTTCCC