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Peptide record

TPDB63355

PS-STAT3-K685R peptide Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB63355
PS-STAT3-K685R peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Phosphorothioated (PS) polymer
Sequence
PDIPKEEAFGRYCRPESQEHPC
Physicochemical Analysis
C111H166N32O36S2
NLMTWV
EP
2588.85
4.76
4
5
4
-2
12.37
-1.450
22.27
Mammalian: >20 hour Yeast: >20 hour E.coli: ?
1615
62.38
5
Residue Composition
number
1
A
2
R
0
N
1
D
2
C
4
E
1
Q
1
G
1
H
1
I
0
L
1
K
0
M
1
F
4
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 2 E: 4 Q: 1 G: 1 H: 1 I: 1 L: 0 K: 1 M: 0 F: 1 P: 4 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
22
C111H166N32O36S2
2588.85
4.76
-2
12.37
-1.450
Free
Phosphorothioated (PS) polymer
L
Linear
Free
N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Murine B16 Melanoma, Human Hct116 Colon Carcinoma, Human Lovo Metastatic Crc, U251 Human Glioma Cell, Kpc Mouse Cell

Assay & Model

NSG mice bearing HCT116 tumor cells
NSG mice bearing HCT116 tumor cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM dye and Oligonucleotide
Probably Cytoplasm
In vitro and in vivo
CCSCCCSCC
Additional Detail Fields 1 fields
CCSCCCSCC