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Peptide record

TPDB63338

Peptide 48 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63338
Peptide 48
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 12-aa standard-residue cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
NYTTYKSHFQDR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C69H98N20O22
ACEGILMPWV
TY
1559.66
9.56
3
1
3
+1
4.32
-2.008
0.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
2980
1.91
7
Residue Composition
number
0
A
1
R
1
N
1
D
0
C
0
E
1
Q
0
G
1
H
0
I
0
L
1
K
0
M
1
F
0
P
1
S
2
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 0 L: 0 K: 1 M: 0 F: 1 P: 0 S: 1 T: 2 W: 0 Y: 2 V: 0
Chemical Descriptors
12 reviewed residue count
C69H98N20O22 sequence-only estimate (linear, free termini)
1559.66 sequence-only estimate (linear, free termini)
9.56 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
4.32 sequence-only estimate (linear, free termini)
-2.008 sequence-only estimate (linear, free termini)
L Activity
Linear Activity
N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Calu 3 cells

Source & Reference

CPPsite3.0
CPPsite3
US 6881825

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Phages
In vitro
CCSSTTSSCCC
Additional Detail Fields 1 fields
CCSSTTSSCCC