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Peptide record

TPDB63331

EDN(32-41) GBP(EDN) Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63331
EDN(32-41) GBP(EDN)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
NYQRRCKNQN
Physicochemical Analysis
C52H86N22O17S1
ADEGHILMFPSTWV
N
1323.45
10.42
3
0
1
+3
3.85
-2.920
0.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
1490
112.58
7
Residue Composition
number
0
A
2
R
3
N
0
D
1
C
0
E
2
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 3 D: 0 C: 1 E: 0 Q: 2 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
10
C52H86N22O17S1
1323.45
10.42
+3
3.85
-2.920
Free
L
Cationic
Linear
Free
N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)O N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Beas-2B, A549, Caco-2 and AGS

Assay & Model

Female Sprague-Dawley rats
Female Sprague-Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (FITC)
Cytoplasm and nucleus
In vitro and in vivo
CCBTTBCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
TMR at N terminal
TMR-GBP(ECP) internalization as 100%, GBP(EDN) and GBP(ECP(W4R)) exhibited 23% and 21% decreases in internalization, respectively.
In vitro
CCSSSCSCCC
Additional Detail Fields 1 fields
CCBTTBCCCC CCSSSCSCCC