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Peptide record

TPDB63328

Peptide 1-C3G Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63328
Peptide 1-C3G
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 10-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Sequence
NTGTWLKYHS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C55H79N15O16
ARDCEQIMFPV
T
1206.32
9.74
2
0
3
+1
1.73
-1.160
39.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
6990
5.79
5
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
1
L
1
K
0
M
0
F
0
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
10 reviewed residue count
C55H79N15O16 sequence-only estimate (linear, free termini)
1206.32 sequence-only estimate (linear, free termini)
9.74 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
1.73 sequence-only estimate (linear, free termini)
-1.160 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87MG cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
Lower than peptide 1
In vitro
CCCCSCCCC
Additional Detail Fields 1 fields
CCCCSCCCC