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Peptide record

TPDB63327

Peptide 1 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63327
Peptide 1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 10-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Sequence
NTCTWLKYHS
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C56H81N15O16S1
ARDEQGIMFPV
T
1252.41
8.88
2
0
3
+1
1.70
-0.870
39.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
6990
5.58
6
Residue Composition
number
0
A
0
R
1
N
0
D
1
C
0
E
0
Q
0
G
1
H
0
I
1
L
1
K
0
M
0
F
0
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
10 reviewed residue count
C56H81N15O16S1 sequence-only estimate (linear, free termini)
1252.41 sequence-only estimate (linear, free termini)
8.88 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
1.70 sequence-only estimate (linear, free termini)
-0.870 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87MG cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
High
In vitro
CCCSSCCCC
Additional Detail Fields 1 fields
CCCSSCCCC