Back to search

Peptide record

TPDB63320

BBBpS_9 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63320
BBBpS_9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
NRPDSAQFWLHH-NH2
Physicochemical Analysis
C68H94N22O18
CEGIKMTYV
H
1507.63
8.00
3
1
4
+0
1.83
-1.358
40.83
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5500
364.81
3
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
0
E
1
Q
0
G
2
H
0
I
1
L
0
K
0
M
1
F
1
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 2 I: 0 L: 1 K: 0 M: 0 F: 1 P: 1 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C68H94N22O18
1507.63
8.00
+0
1.83
-1.358
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hebc-5I, Hs68, HeLa, MDA-MB-231 And Hek-293 Cells

Assay & Model

7-weeks old CD1 female mice
7-weeks old CD1 female mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
CF dye and Ga-radiolabed for in-vivo
Translocation = 46.0±4.3%
In vitro and in vivo
CBCSSCCSSSSCCBCC
Additional Detail Fields 1 fields
CBCSSCCSSSSCCBCC