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Peptide record

TPDB63319

E8 Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB63319
E8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 13-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
NRHFRFFFNFTNR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C85H115N27O18
ADCEQGILKMPSWYV
F
1803.02
12.70
4
0
5
+3
4.39
-1.069
0.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
4
Residue Composition
number
0
A
3
R
3
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
5
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 3 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 5 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
13 reviewed residue count
C85H115N27O18 sequence-only estimate (linear, free termini)
1803.02 sequence-only estimate (linear, free termini)
12.70 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
4.39 sequence-only estimate (linear, free termini)
-1.069 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

C166-eGFP cells

Source & Reference

CPPsite3.0
CPPsite3
WO 2011/020188 A1

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nucleic acid (siRNA)
In vitro
CCSCCCCCCCCC
Additional Detail Fields 1 fields
CCSCCCCCCCCC