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Peptide record

TPDB63301

Transkin (CPP3) Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63301
Transkin (CPP3)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
NGSLNTHLAPIL
Physicochemical Analysis
C55H92N16O17
RDCEQKMFWYV
L
1249.43
7.85
1
0
5
+0
0.37
0.333
138.33
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
0
0.00
4
Residue Composition
number
1
A
0
R
2
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
3
L
0
K
0
M
0
F
1
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 3 K: 0 M: 0 F: 0 P: 1 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C55H92N16O17
1249.43
7.85
+0
0.37
0.333
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16-F10 Cells , PC-12 Cells ,B16-F10 And Human Dermal Fibroblasts (Hdfs)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FITC at N terminal
CPP-3 displayed the highest cellular uptake at 56.4%
In vitro
CCCCSSCSCCGGGCC
Additional Detail Fields 1 fields
CCCCSSCSCCGGGCC