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Peptide record

TPDB63298

CPP3 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB63298
CPP3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: IR780-labeled usNLCs
Sequence
NFLQWVPTLK-NH2
Physicochemical Analysis
C61H92N14O14
ARDCEGHIMSY
L
1245.49
10.10
1
0
5
+1
-1.45
0.050
107.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5500
441.59
3
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
2
L
1
K
0
M
1
F
1
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 2 K: 1 M: 0 F: 1 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
10
C61H92N14O14
1245.49
10.10
+1
-1.45
0.050
Amidation
IR780-labeled usNLCs
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hbmec Cell Monolayer And U87 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Celecoxib (CXB)
Uptake across the BBB = CPP4 > CPP2 >CPP3 > CPP5 > c(RGDfK) > CPP3. CPP3 significantly have a higher affinity for cell uptake in U87.
Non-dependent energy pathway (e.g., direct translocation).
In vitro and ex vivo
CCCCCSCCCC
Additional Detail Fields 1 fields
CCCCCSCCCC