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Peptide record

TPDB63292

Sub peptide14–39 Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB63292
Sub peptide14–39
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
NEPCDSDGDCCTSSEQCISTGSKYFC
Physicochemical Analysis
C108H163N29O47S5
ARHLMWV
CS
2779.95
3.43
1
5
3
-4
7.54
-0.681
15.00
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
1740
62.59
15
Residue Composition
number
0
A
0
R
1
N
3
D
5
C
2
E
1
Q
2
G
0
H
1
I
0
L
1
K
0
M
1
F
1
P
5
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 3 C: 5 E: 2 Q: 1 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 1 S: 5 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
26
C108H163N29O47S5
2779.95
3.43
-4
7.54
-0.681
Free
L
Hydrophilic
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Cardiomyocytes And Hepatocytes Tested: Sk-Mel-188, Hep G2, Caco-2, MDA-MB-231, A549 And Du 145 Huv-Ec-C, Mcr-5, Hff-1, Hek-293, Bhk- 21 And Mdck

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophilic
Synthetic
Nucleus
The sub peptide14–39 is directed to the nuclear region within 20 min, similar to synthetic CPP-Ts. It presented nuclear localization in rat cardiomyocytes and rat hepatocytes the sub-peptide was unable to cross the cell membrane in all the six normal immortalized cell lines(HUV-EC-C, HFF-1, MCR-5, HEK-293, BHK-21 and MDCK) and it was internalized and directed to the intranuclear region in all six neoplastic cell lines analyzed (SK-MEL-188, HEP G2,Caco-2, MDA-MB-231, A549 and DU 145)
In vitro
CCCCHHHHTTCCCCSCCSCCSGGGGSCHHHHHHHCCCCCSCCCC
Additional Detail Fields 1 fields
CCCCHHHHTTCCCCSCCSCCSGGGGSCHHHHHHHCCCCCSCCCC