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Peptide record

TPDB63285

ZF5.3 Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB63285
ZF5.3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
MYSCNVCGKAFVLSRHLNRHLRVHRRAT
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C142H234N52O35S3
DEQIPW
R
3325.93
11.83
9
0
11
+6
2.77
-0.346
80.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1615
0.49
8
Residue Composition
number
2
A
5
R
2
N
0
D
2
C
0
E
0
Q
1
G
3
H
0
I
3
L
1
K
1
M
1
F
0
P
2
S
1
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 2 R: 5 N: 2 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 3 I: 0 L: 3 K: 1 M: 1 F: 1 P: 0 S: 2 T: 1 W: 0 Y: 1 V: 3
Chemical Descriptors
28 reviewed residue count
C142H234N52O35S3 sequence-only estimate (linear, free termini)
3325.93 sequence-only estimate (linear, free termini)
11.83 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
2.77 sequence-only estimate (linear, free termini)
-0.346 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ai9 Tdtomato Npcs

Assay & Model

Ai9 or wild-type mice
Ai9 or wild-type mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
SpyCas9 RNPs
In vitro and in vivo
CCCCCSCCSCCCCCC
Additional Detail Fields 1 fields
CCCCCSCCSCCCCCC