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Peptide record

TPDB63281

M918-anti-gyrA PNA/scPNA M918 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB63281
M918-anti-gyrA PNA/scPNA M918
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
MVTVLFRRLRIRRACGPPRVRV
Physicochemical Analysis
C116H207N43O24S2
NDEQHKSWY
R
2652.31
12.80
7
0
10
+7
3.80
0.095
110.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
7
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
1
I
2
L
0
K
1
M
1
F
2
P
0
S
1
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 1 R: 7 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 0 M: 1 F: 1 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 4
Chemical Descriptors
22
C116H207N43O24S2
2652.31
12.80
+7
3.80
0.095
Free
L
Hydrophobic Amphipathic
Linear
Free
N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)O N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HT-29-luc cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
PNA
Endocytosis
In vitro
CCTTHHHHSSSCSCCSSSSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Hydrophobic
Protein derived
HIV-1 Nef and Hsp20-Nef proteins
M918 transfer Nef and Hsp20-Nef proteins into the cells.
In vitro
CCTTHHHHSSSCSCCSSSSSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

S. Pyogenes Strains

Assay & Model

G. mellonella Larvae
G. mellonella Larvae

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
anti-gyrA antisense PNAs and scrambled PNAs [scPNAs]
In vitro and in vivo
CCSSCGGGHHHHSCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Assay & Model

8 to 7 week-old female BALB/c mice
8 to 7 week-old female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Protein derived
Protein (HIV-1 Nef or Hsp20-Nef proteins) and FITC-antibody
Effectively delivered protein
In vitro and in vivo
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCTTHHHHSSSCSCCSSSSSCC CCSSCGGGHHHHSCCC CCCSSSTTCCCTTTTC