Back to search

Peptide record

TPDB63274

NNJA_19 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63274
NNJA_19
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
MTSSRDAPA
Physicochemical Analysis
C36H62N12O15S1
NCEQGHILKFWYV
AS
935.02
6.78
1
1
3
-0
2.32
-0.711
22.22
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
1
R
0
N
1
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
1
M
0
F
1
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 1 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C36H62N12O15S1
935.02
6.78
-0
2.32
-0.711
Free
L
Hydrophobic
Linear
Free
N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek, N2A And SH-SY5Y Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Phage Display
siHPRT-Alexa647
Cytosol
Internalization was observed with both conjugates with comparable level in HEK cells
Direct membrane translocation and Endocytosis
In vitro
CCSCCCCCC
Additional Detail Fields 1 fields
CCSCCCCCC