Back to search

Peptide record

TPDB63265

NNJA_28 Cell-penetrating Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63265
NNJA_28
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 9-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
MSLKSTPHP
Physicochemical Analysis
C43H72N12O13S1
ARNDCEQGIFWYV
PS
997.18
10.10
2
0
2
+1
2.46
-0.767
43.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
1
L
1
K
1
M
0
F
2
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 1 M: 1 F: 0 P: 2 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C43H72N12O13S1
997.18
10.10
+1
2.46
-0.767
Free
L
Hydrophobic
Linear
Free
N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek-239 ,Caco2 Cells, SH-SY5Y Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Phage Display
IgG4 antibody
Cytosol
Substantial levels of antibodies internalization in cells apart from CPP-12-AF488 peptide (no cargo attached) which showed no uptake after 3 hr and 24 hr incubation.
In vitro
CCSSSSCCC
Additional Detail Fields 1 fields
CCSSSSCCC