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Peptide record

TPDB63261

Bac-ELP-H1 Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB63261
Bac-ELP-H1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Conjugation with ELP-Rho
Sequence
MRRIRPRPPRLPRPRPRPLPFPRPGGCYPG
Physicochemical Analysis
C159H261N57O32S2
ANDEQHKSTWV
P
3547.30
12.70
9
0
6
+9
8.30
-1.377
39.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
42.00
2
Residue Composition
number
0
A
9
R
0
N
0
D
1
C
0
E
0
Q
3
G
0
H
1
I
2
L
0
K
1
M
1
F
11
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 0 M: 1 F: 1 P: 11 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
30
C159H261N57O32S2
3547.30
12.70
+9
8.30
-1.377
Conjugation with ELP-Rho
L
Cationic
Linear
Free
N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human U-87-MG and D54 glioma cells along with the rat C6 glioma cells

Assay & Model

Female Sprague Dawley rats
Female Sprague Dawley rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Peptide (Rhodamine labeled ELP)
Significantly enhancing brain tumor deposition of the ELP carrier
In vitro and in vivo
CCCBCCCSTTCCCSCCBCSSCSSSCSSSCC
Additional Detail Fields 1 fields
CCCBCCCSTTCCCSCCBCSSCSSSCSSSCC