TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63261

Peptide_Name

Bac-ELP-H1

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP

Sequence_Type

modified_plain

Has_Modification Yes

Description A 30-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.

Modification

C-terminal: Conjugation with ELP-Rho

Sequence

MRRIRPRPPRLPRPRPRPLPFPRPGGCYPG

FASTA

>TPDB63261|Cell-penetrating Peptides|length=30
MRRIRPRPPRLPRPRPRPLPFPRPGGCYPG

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

30 reviewed residue count

C_terminal_Modification

Conjugation with ELP-Rho Activity

Chirality

L Activity

Ionic_State

Cationic Activity

Linearity

Linear Activity

N_terminal_Modification

Free Activity

SMILES

N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human U-87-MG and D54 glioma cells along with the rat C6 glioma cells

Assay & Model

In Vitro Model Female Sprague Dawley rats

In Vivo Model Female Sprague Dawley rats

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L Cationic

Source of Peptide Protein derived

Cargo Type Peptide (Rhodamine labeled ELP)

Uptake Efficiency Significantly enhancing brain tumor deposition of the ELP carrier

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCBCCCSTTCCCSCCBCSSCSSSCSSSCC

DSSP_Secondary_Structure

CCCBCCCSTTCCCSCCBCSSCSSSCSSSCC