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Peptide record

TPDB63256

TatU1A-LL-Alexa549 Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB63256
TatU1A-LL-Alexa549
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: Alexa Fluor 546 at Cys
Sequence
MQGFPFYDKPMRIQYAKTDSDIIAKMKLLC
Physicochemical Analysis
C161H255N39O43S4
NEHWV
K
3553.27
9.45
5
3
14
+2
3.34
-0.227
71.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
83.87
7
Residue Composition
number
2
A
1
R
0
N
3
D
1
C
0
E
2
Q
1
G
0
H
3
I
2
L
4
K
3
M
2
F
2
P
1
S
1
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 3 C: 1 E: 0 Q: 2 G: 1 H: 0 I: 3 L: 2 K: 4 M: 3 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 2 V: 0
Chemical Descriptors
30
C161H255N39O43S4
3553.27
9.45
+2
3.34
-0.227
Addition of Cysteine
Alexa Fluor 546 at Cys
L
Linear
Free
N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
shRNA and U1A protein
Cytoplasm
TatU1A-LL-Alexa546 showed the highest endosomal escape efficiencies of around 80%
Photochemical internalization
In vitro
CCSSCCCCSSSCCCCSSSCSCTTCTTTCCC
Additional Detail Fields 1 fields
CCSSCCCCSSSCCCCSSSCSCTTCTTTCCC