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Peptide record

TPDB63228

RL2(Dimer) Cell-penetrating Peptides standard
120 amino acids
Basic Information
3D PDB MODEL
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TPDB63228
RL2(Dimer)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 120-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
MNQKQPAHENPYVPRTYYAKKIQDKIIIPNDERPFYQKTNPAVVRPHAQTIGGSHHHHHAPYVPMYYVPNSYPYYGTNLYQRRPAIAINIPQRQYLPNSHPPTVVRRPNLHPSFIAIPPH
Physicochemical Analysis
C643H964N186O167S2
CW
P
14035.99
10.16
23
4
44
+10
26.55
-0.891
65.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
17880
127.39
38
Residue Composition
number
8
A
8
R
9
N
2
D
0
C
2
E
8
Q
3
G
10
H
10
I
3
L
5
K
2
M
2
F
20
P
4
S
5
T
0
W
12
Y
7
V
Amino Acid Distribution
A: 8 R: 8 N: 9 D: 2 C: 0 E: 2 Q: 8 G: 3 H: 10 I: 10 L: 3 K: 5 M: 2 F: 2 P: 20 S: 4 T: 5 W: 0 Y: 12 V: 7
Chemical Descriptors
120
C643H964N186O167S2
14035.99
10.16
+10
26.55
-0.891
Free
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Endosomes And Cytoplasm
RL2 is localized in endosomes and in the cytoplasm of A549 cells after their incubation with RL2.
Lipid-raft mediated endocytosis
In vitro
CCCSCCSSSSTTHHHHCC
Additional Detail Fields 1 fields
CCCSCCSSSSTTHHHHCC