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Peptide record

TPDB63220

NCAM11–19PrP23–28 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB63220
NCAM11–19PrP23–28
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard-residue cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
MLRTKDLIWTLFFLGTAVSKKRPKP
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C139H228N36O32S1
NCEQHY
LK
2947.62
11.63
6
1
11
+5
1.19
-0.092
93.60
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
1.87
4
Residue Composition
number
1
A
2
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
4
L
4
K
1
M
2
F
2
P
1
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 4 M: 1 F: 2 P: 2 S: 1 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
25 reviewed residue count
C139H228N36O32S1 sequence-only estimate (linear, free termini)
2947.62 sequence-only estimate (linear, free termini)
11.63 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
1.19 sequence-only estimate (linear, free termini)
-0.092 sequence-only estimate (linear, free termini)
Free Activity
L Activity
Linear Activity
Free Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87 or SH-SY5Y cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Chimeric
Aβ42–EGFP fusion protein expressing plasmid
Efficiently Internalized
In vitro