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Peptide record

TPDB63218

ZiF Cell-penetrating Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB63218
ZiF
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 37-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with Snap-Tag
Sequence
MLEPGEKPYKCPECGKSFSASAALVAHQRTHTGKKTS
Physicochemical Analysis
C171H276N50O53S3
NDIW
K
3976.56
9.53
8
3
10
+3
12.13
-0.765
39.73
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1615
40.61
11
Residue Composition
number
4
A
1
R
0
N
0
D
2
C
3
E
1
Q
3
G
2
H
0
I
2
L
5
K
1
M
1
F
3
P
4
S
3
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 0 C: 2 E: 3 Q: 1 G: 3 H: 2 I: 0 L: 2 K: 5 M: 1 F: 1 P: 3 S: 4 T: 3 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C171H276N50O53S3
3976.56
9.53
+3
12.13
-0.765
Free
L
Linear
Conjugated with Snap-Tag
N[C@@H](CCSC)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Saos-2 Cells , HeLa And Sk-Hep-1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Rho-labeled SNAP-tag (enzyme)
Cytosol
Nearly 5-fold higher than SNAP-Rho
Endocytosis
In vitro
CCSSCTTCSSCSSTTSSSHHHHHHHHHHHGGGGSCC
Additional Detail Fields 1 fields
CCSSCTTCSSCSSTTSSSHHHHHHHHHHHGGGGSCC