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Peptide record

TPDB63217

WaTx peptide Cell-penetrating Peptides standard
68 amino acids
Basic Information
3D PDB MODEL
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TPDB63217
WaTx peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 68-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Liposomes
Sequence
MKYFTLALTLLFLLLINPCKDMNFAWAESSEKVERASPQQAKYCYEQCNVNKVPFDQCYQMCSPLERS
Physicochemical Analysis
C356H547N89O103S8
GH
L
7978.27
6.32
7
7
29
-0
8.99
-0.243
71.76
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11710
146.77
25
Residue Composition
number
5
A
2
R
4
N
2
D
5
C
5
E
5
Q
0
G
0
H
1
I
8
L
5
K
3
M
4
F
4
P
5
S
2
T
1
W
4
Y
3
V
Amino Acid Distribution
A: 5 R: 2 N: 4 D: 2 C: 5 E: 5 Q: 5 G: 0 H: 0 I: 1 L: 8 K: 5 M: 3 F: 4 P: 4 S: 5 T: 2 W: 1 Y: 4 V: 3
Chemical Descriptors
68
C356H547N89O103S8
7978.27
6.32
-0
8.99
-0.243
Free
Liposomes
L
Linear
Free
N[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek Cells

Assay & Model

Adult (12–28 week-old) C57BL/6J mice
Adult (12–28 week-old) C57BL/6J mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
AlexaFluor568-IgG
Toxin readily crossed the liposome bilayer with a rate-constant linearly related to concentration.
Passive cell penetration
In vitro and in vivo
CCCSSSTTTTCCCC
Additional Detail Fields 1 fields
CCCSSSTTTTCCCC