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Peptide record

TPDB63192

L1 Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB63192
L1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with CF
Sequence
MIILIIGSTSRDHMVLHEYVNAAGIT-NH2
Physicochemical Analysis
C126H208N34O37S2
CQKFPW
I
2855.36
6.02
3
2
14
-1
2.69
0.746
135.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
52.18
6
Residue Composition
number
2
A
1
R
1
N
1
D
0
C
1
E
0
Q
2
G
2
H
5
I
2
L
0
K
2
M
0
F
0
P
2
S
2
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 2 I: 5 L: 2 K: 0 M: 2 F: 0 P: 0 S: 2 T: 2 W: 0 Y: 1 V: 2
Chemical Descriptors
26
C126H208N34O37S2
2855.36
6.02
-1
2.69
0.746
Amidation
L
Hydrophobic
Linear
Conjugated with CF
N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293T, Jurkat E6.1 Leukemia Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
carboxyfluorescein(CF) dye
Cytoplasm
13 percent of the uptake measured for R9
Endocytosis
In vitro
CCCSCSCCCCCC
Additional Detail Fields 1 fields
CCCSCSCCCCCC