TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63191

Peptide_Name

L-TCTP-PTD 13M1 TCTP-PTD 13M1

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 12-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acetylation

Sequence

Ac-MIIFRLLISHKK-NH2

Source representation

>TPDB63191|Cell-penetrating Peptides|length=12
Ac-MIIFRLLISHKK-NH2

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

12 reviewed residue count

C_terminal_Modification

Amidation Activity

Chirality

L Activity

Linearity

Linear Activity

N_terminal_Modification

Acetylation Activity

SMILES

N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Assay & Model

In Vitro Model Male Wistar rats and C57BL/6 db/db mice at 6 weeks of age

In Vivo Model Male Wistar rats and C57BL/6 db/db mice at 6 weeks of age

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Exendin-4 protein

Uptake Efficiency TCTP-PTD 13M2 showed the highest exendin-4 uptake among the three analogs in normal rats

In Vitro or In Vivo In vivo

DSSP Secondary Structure CCCBTTBTSCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Beas-2B Human Bronchial Epithelial Cells

Assay & Model

In Vitro Model Male Wistar rats and ICR mice (5-week old)

In Vivo Model Male Wistar rats and ICR mice (5-week old)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Insulin and FITC-labeled at N terminus

Uptake Efficiency Ccapacity of l-TCTP-PTD 13M1 was lower than l-TCTP-PTD 13

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCTTTTTSSCC

DSSP_Secondary_Structure

CCCBTTBTSCC CCTTTTTSSCC