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Peptide record

TPDB63189

L-TCTP-PTD 13M2 TCTP-PTD 13M2 PTD4 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63189
L-TCTP-PTD 13M2 TCTP-PTD 13M2 PTD4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-MIIFRLLASHKK-NH2
Physicochemical Analysis
C68H117N19O14S1
NDCEQGPTWYV
ILK
1456.86
11.64
4
0
7
+3
0.61
0.567
138.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
2
I
2
L
2
K
1
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 2 K: 2 M: 1 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C68H117N19O14S1
1456.86
11.64
+3
0.61
0.567
Amidation
L
Linear
Acetylation
N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Male Wistar rats and C57BL/6 db/db mice at 6 weeks of age
Male Wistar rats and C57BL/6 db/db mice at 6 weeks of age

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Exendin-4 protein
TCTP-PTD 13M2 showed the highest exendin-4 uptake among the three analogs in normal rats
In vivo
CTTSHHHHSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Female wistar rats
Female wistar rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Insulin
PTD1 as an absorption enhancer was relatively lower than that of PTD4 at pH 4.5
In vivo
CCTTTTTSSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Beas-2B Human Bronchial Epithelial Cells

Assay & Model

Male Wistar rats and ICR mice (5-week old)
Male Wistar rats and ICR mice (5-week old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Insulin and FITC-labeled at N terminus
Exhibited 1.77-fold higher uptake than l-TCTP-PTD 13
In vitro and in vivo
CCCBTTBTSCC
Additional Detail Fields 1 fields
CTTSHHHHSCC CCTTTTTSSCC CCCBTTBTSCC