TPDB

3D PDB MODEL

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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB ID TPDB63189

Peptide_Name

L-TCTP-PTD 13M2 TCTP-PTD 13M2 PTD4

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

modified_plain

Has_Modification Yes

Description A 12-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acetylation

Sequence

Ac-MIIFRLLASHKK-NH2

Source representation

>TPDB63189|Cell-penetrating Peptides|length=12
Ac-MIIFRLLASHKK-NH2

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Length

12 reviewed residue count

C_terminal_Modification

Amidation Activity

Chirality

L Activity

Linearity

Linear Activity

N_terminal_Modification

Acetylation Activity

SMILES

N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O Activity

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Assay & Model

In Vitro Model Male Wistar rats and C57BL/6 db/db mice at 6 weeks of age

In Vivo Model Male Wistar rats and C57BL/6 db/db mice at 6 weeks of age

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Exendin-4 protein

Uptake Efficiency TCTP-PTD 13M2 showed the highest exendin-4 uptake among the three analogs in normal rats

In Vitro or In Vivo In vivo

DSSP Secondary Structure CTTSHHHHSCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Assay & Model

In Vitro Model Female wistar rats

In Vivo Model Female wistar rats

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Insulin

Uptake Efficiency PTD1 as an absorption enhancer was relatively lower than that of PTD4 at pH 4.5

In Vitro or In Vivo In vivo

DSSP Secondary Structure CCTTTTTSSCC

Evidence 3 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Beas-2B Human Bronchial Epithelial Cells

Assay & Model

In Vitro Model Male Wistar rats and ICR mice (5-week old)

In Vivo Model Male Wistar rats and ICR mice (5-week old)

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Source of Peptide Synthetic

Cargo Type Insulin and FITC-labeled at N terminus

Uptake Efficiency Exhibited 1.77-fold higher uptake than l-TCTP-PTD 13

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCBTTBTSCC

DSSP_Secondary_Structure

CTTSHHHHSCC CCTTTTTSSCC CCCBTTBTSCC