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Peptide record

TPDB63183

L- TCTP-PTD 13 L-TCTP-PTD 13 TCTP-PTD 13 PTD1 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63183
L- TCTP-PTD 13 L-TCTP-PTD 13 TCTP-PTD 13 PTD1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acetylation
Sequence
Ac-MIIFRALISHKK-NH2
Physicochemical Analysis
C68H117N19O14S1
NDCEQGPTWYV
I
1456.86
11.64
4
0
7
+3
0.86
0.625
138.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
3
I
1
L
2
K
1
M
1
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 3 L: 1 K: 2 M: 1 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C68H117N19O14S1
1456.86
11.64
+3
0.86
0.625
Amidation
L
Linear
Acetylation
N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Beas-2B Cells

Assay & Model

Female BALB/c mice
Female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Antigen ovalbumin (OVA) and FITC-labeled at N terminus
D-TCTP-PTD 13 was internalized 1.6 times more efficiently than L-amino acid counterpart in BEAS-2B cells
In vitro and in vivo
CCTTTTTSSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Male Wistar rats and C57BL/6 db/db mice at 6 weeks of age
Male Wistar rats and C57BL/6 db/db mice at 6 weeks of age

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Exendin-4 protein
TCTP-PTD 13M2 showed the highest exendin-4 uptake among the three analogs in normal rats
In vivo
CCTTTTTSSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Female wistar rats
Female wistar rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Insulin
PTD1 as an absorption enhancer was relatively lower than that of PTD4 at pH 4.4
In vivo
CCTTSSCCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Beas-2B Human Bronchial Epithelial Cells

Assay & Model

Male Wistar rats and ICR mice (5-week old)
Male Wistar rats and ICR mice (5-week old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
Insulin and FITC-labeled at N terminus
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTTTTSSCC CCTTSSCCCCC