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Peptide record

TPDB63175

pHKa Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB63175
pHKa
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugated with Alexa Fluor 488
Sequence
MIASHLLAYFFTELN-NH2
Physicochemical Analysis
C84H124N18O22S1
RDCQGKPWV
L
1770.08
5.13
1
1
10
-1
-2.09
0.933
117.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
84.18
4
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
1
H
1
I
3
L
0
K
1
M
2
F
0
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 0 M: 1 F: 2 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C84H124N18O22S1
1770.08
5.13
-1
-2.09
0.933
Amidation
L
Linear
Conjugated with Alexa Fluor 488
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, CHO-K1, Or Pgsa-745 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Alexa 488 dye
Cytosol
pHKA488 showed weak and similar uptake in all 3 cell lines.
Energy-independent mechanisms and macropinocytosis
In vitro
CCCCCCC
Additional Detail Fields 1 fields
CCCCCCC