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Peptide record

TPDB63174

Peptide 6 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB63174
Peptide 6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia
standard
No
A 12-aa standard-residue cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
Sequence
MHKRPTTPSRKM
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C61H108N22O16S2
ANDCEQGILFWYV
RKMPT
1469.79
12.42
5
0
2
+4
4.12
-1.800
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
2
K
2
M
0
F
2
P
1
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 2 M: 2 F: 0 P: 2 S: 1 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
12 reviewed residue count
C61H108N22O16S2 sequence-only estimate (linear, free termini)
1469.79 sequence-only estimate (linear, free termini)
12.42 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
4.12 sequence-only estimate (linear, free termini)
-1.800 sequence-only estimate (linear, free termini)
L Activity
Linear Activity
N[C@@H](CCSC)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HIG-82 cells

Source & Reference

CPPsite3.0
CPPsite3
US 6881825

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Protein (?-galactosidase), Phages
In vitro
CCCCSCCGGGC
Additional Detail Fields 1 fields
CCCCSCCGGGC