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Peptide record

TPDB63169

aPP5.3 Cell-penetrating Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB63169
aPP5.3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 37-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with Snap-Tag
Sequence
MGPSQPTYPGDDAPVRDLIRFYRDLRRYLNVVTRHRY
Physicochemical Analysis
C200H310N62O55S1
CEKW
R
4495.10
10.16
8
4
14
+3
7.71
-0.954
68.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5960
132.59
9
Residue Composition
number
1
A
7
R
1
N
4
D
0
C
0
E
1
Q
2
G
1
H
1
I
3
L
0
K
1
M
1
F
4
P
1
S
2
T
0
W
4
Y
3
V
Amino Acid Distribution
A: 1 R: 7 N: 1 D: 4 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 1 L: 3 K: 0 M: 1 F: 1 P: 4 S: 1 T: 2 W: 0 Y: 4 V: 3
Chemical Descriptors
37
C200H310N62O55S1
4495.10
10.16
+3
7.71
-0.954
Free
L
Linear
Conjugated with Snap-Tag
N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Saos-2 Cells , HeLa And Sk-Hep-1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Rho-labeled SNAP-tag (enzyme)
Cytosol
2-fold higher than that observed than SNAP-Rho
Endocytosis
In vitro
CCCSCCCCSSSTTTSSCCSSCSSCC
Additional Detail Fields 1 fields
CCCSCCCCSSSTTTSSCCSSCSSCC