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Peptide record

TPDB63164

CC12S Cell-penetrating Peptides modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63164
CC12S
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 13-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FITC
Sequence
MFPPMILETSERK
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
13 reviewed residue count
Conjugated with FITC Activity
L Activity
Linear Activity
Free Activity
N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

ARPE-19 And HUVECs Rabbit (Adult Albino Rabbits (2.5 Kg)) Cornea And Sclera-CHOroid-Retina Complexes

Assay & Model

Male Sprague-Dawley rats (0.15 kg), neonatal C57BL/6J mice with mothers
Male Sprague-Dawley rats (0.15 kg), neonatal C57BL/6J mice with mothers

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
CC12S-FITC peptides barely entered ARPE-19 cells show weak fluorescence
In-vitro, in-vivo and ex vivo
CCCSSCCCCCCCC
Additional Detail Fields 1 fields
CCCSSCCCCCCCC