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Peptide record

TPDB63160

Tat(1-72) Cell-penetrating Peptides standard
72 amino acids
Basic Information
3D PDB MODEL
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TPDB63160
Tat(1-72)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 72-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Aβ fibril
Sequence
MEPVDPRLEPWKHPGSQPKTACTTCYCKKCCFHCQVCFTTKALGISYGRKKRRQRRRPPQGSQTHQVSLSKQ
Physicochemical Analysis
C357H577N115O99S8
N
K
8320.70
10.28
18
3
15
+12
20.46
-1.037
36.53
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
8855
106.42
27
Residue Composition
number
2
A
7
R
0
N
1
D
7
C
2
E
7
Q
4
G
3
H
1
I
3
L
8
K
1
M
2
F
7
P
5
S
6
T
1
W
2
Y
3
V
Amino Acid Distribution
A: 2 R: 7 N: 0 D: 1 C: 7 E: 2 Q: 7 G: 4 H: 3 I: 1 L: 3 K: 8 M: 1 F: 2 P: 7 S: 5 T: 6 W: 1 Y: 2 V: 3
Chemical Descriptors
72
C357H577N115O99S8
8320.70
10.28
+12
20.46
-1.037
Free
Aβ fibril
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rat Hippocampal Neurons

Assay & Model

Six-month-old transgenic C57BL-6 mice
Six-month-old transgenic C57BL-6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Venus-labelled
Tat protein was localized to the amyloid plaques and Tat colocalizes with APP in the brains of APP-Tat double transgenic mice.
In vitro and in vivo
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC