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Peptide record

TPDB63155

LAMBDA N (1-22) Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB63155
LAMBDA N (1-22)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with fluorescein by C-terminal Gly Cys amide
Sequence
MDAQTRRRERRAEKQAQWKAANGC
Physicochemical Analysis
C115H194N46O36S2
HILFPSYV
AR
2861.21
11.25
7
3
7
+4
10.44
-1.808
20.83
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
192.23
6
Residue Composition
number
5
A
5
R
1
N
1
D
1
C
2
E
3
Q
1
G
0
H
0
I
0
L
2
K
1
M
0
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 5 N: 1 D: 1 C: 1 E: 2 Q: 3 G: 1 H: 0 I: 0 L: 0 K: 2 M: 1 F: 0 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
24
C115H194N46O36S2
2861.21
11.25
+4
10.44
-1.808
Conjugation with fluorescein by C-terminal Gly Cys amide
L
Cationic
Linear
Free
N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

RAW 264.7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasm and nucleus
Less relative to Tat-(48–60) peptide
Non-endocytic mechanism
In vitro
CCCCCHHHHTTTSSSSCCCCCCCC
Additional Detail Fields 1 fields
CCCCCHHHHTTTSSSSCCCCCCCC