Back to search

Peptide record

TPDB63153

CTX_M1 Cell-penetrating Peptides standard
36 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63153
CTX_M1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 36-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
MCMPCFTTDHQMARRCDDCCGGRGRGKCYGPQCLCR
Physicochemical Analysis
C158H256N56O48S11
NEISWV
C
4060.78
8.10
7
3
7
+3
6.67
-0.581
13.61
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1990
49.01
13
Residue Composition
number
1
A
5
R
0
N
3
D
8
C
0
E
2
Q
5
G
1
H
0
I
1
L
1
K
3
M
1
F
2
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 5 N: 0 D: 3 C: 8 E: 0 Q: 2 G: 5 H: 1 I: 0 L: 1 K: 1 M: 3 F: 1 P: 2 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
36
C158H256N56O48S11
4060.78
8.10
+3
6.67
-0.581
Free
L
Linear
Free
N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And hCMEC/D3 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Alexa Fluor® 488 flourscent dyes
Endosomes
Increase cellular uptake by approximately twofold
Receptor-mediated energy-dependent mechanism
In vitro
CEETTEESSCTTTTTCSSSSGGGSSSCCSSSTTCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Cy5.5™ flourscent dye
Endosomes
Improved internalization by about 80% compared to CTX
Receptor-mediated energy-dependent mechanism
In vitro
CEETTEESSCTTTTTCSSSSGGGSSSCCSSSTTCC
Additional Detail Fields 1 fields
CEETTEESSCTTTTTCSSSSGGGSSSCCSSSTTCC