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Peptide record

TPDB63151

chlorotoxin Cell-penetrating Peptides standard
36 amino acids
Basic Information
3D PDB MODEL
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TPDB63151
chlorotoxin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 36-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
MCMPCETTDHQMARKCDDCCGGKGRGKCYGPQCLCR
Physicochemical Analysis
C154H254N52O50S11
NIFSWV
C
3986.69
7.85
7
4
6
+2
10.18
-0.722
13.61
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1990
49.92
13
Residue Composition
number
1
A
3
R
0
N
3
D
8
C
1
E
2
Q
5
G
1
H
0
I
1
L
3
K
3
M
0
F
2
P
0
S
2
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 3 C: 8 E: 1 Q: 2 G: 5 H: 1 I: 0 L: 1 K: 3 M: 3 F: 0 P: 2 S: 0 T: 2 W: 0 Y: 1 V: 0
Chemical Descriptors
36
C154H254N52O50S11
3986.69
7.85
+2
10.18
-0.722
Free
L
Cyclic
Free
N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Caesarean Derived-1 mice (weighing 25–30 g)
Caesarean Derived-1 mice (weighing 25–30 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Protein derived
125I Radiolabeling
The uptake of chlorotoxin into the brain was higher than that of MCoTI-II but lower than that of dermorphin
In vivo
CCCCCSTTSCTTTTSCCCCSBCSSSCBCCGGGGGC
Additional Detail Fields 1 fields
CCCCCSTTSCTTTTSCCCCSBCSSSCBCCGGGGGC