Back to search

Peptide record

TPDB63147

AA3H-PLP Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB63147
AA3H-PLP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Protein linking peptide (PLP) N-terminal: Conjugated with FITC
Sequence
MASIWVGHRGRRRQQQQQQRRR
Physicochemical Analysis
C115H196N52O30S1
NDCELKFPTY
R
2819.21
13.18
8
0
5
+7
7.77
-2.082
35.45
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
195.09
7
Residue Composition
number
1
A
7
R
0
N
0
D
0
C
0
E
6
Q
2
G
1
H
1
I
0
L
0
K
1
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 6 G: 2 H: 1 I: 1 L: 0 K: 0 M: 1 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C115H196N52O30S1
2819.21
13.18
+7
7.77
-2.082
Free
Protein linking peptide (PLP)
L
Linear
Conjugated with FITC
N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Fibroblasts Cells

Assay & Model

Five weeks-old BALB/c mice
Five weeks-old BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
β-galactosidase and Cre recombinase
β-galactosidase delivered by AA3H produced 298pg/mL of o-nitrophenol, a 6-fold higher amount than obtained with the enzyme delivered by TAT (47pg/mL). AA3H-conjugated Cre exhibited a 2.1-times higher RFP expression level than cells treated with the TAT-conjugated enzyme
In vitro and in vivo
CCSCCSSCCHHHHHHHHHHTC
Additional Detail Fields 1 fields
CCSCCSSCCHHHHHHHHHHTC