TPDB

3D PDB MODEL

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TPDB ID TPDB63146

Peptide_Name

AAH3 (compound 60) AAH3 (compound 66) AAH3 (compound 72)

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

standard

Has_Modification No

Description A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Modification

C-terminal: Amidation N-terminal: Acylation

Sequence

MASIWVGHRG-NH2

FASTA

>TPDB63146|Cell-penetrating Peptides|length=10
MASIWVGHRG-NH2

Formula C49H76N16O12S1

Absent Amino Acids NDCEQLKFPTY

Common Amino Acids G

Mass 1113.30

PI 11.05

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 5

Net Charge +1

Boman Index -0.57

Hydrophobicity 0.220

Aliphatic Index 78.00

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 494.03

Polar Residues 1

number

1

A

1

R

0

N

0

D

0

C

0

E

0

Q

2

G

1

H

1

I

0

L

0

K

1

M

0

F

0

P

1

S

0

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 1 L: 0 K: 0 M: 1 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1

Length

10

Formula

C49H76N16O12S1

Mass

1113.30

PI

11.05

Net Charge

+1

Boman Index

-0.57

Hydrophobicity

0.220

C_terminal_Modification

Amidation

Chirality

L

Linearity

Linear

N_terminal_Modification

Acylation

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human THP-1 Monocyte-Like Cell Line

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Linear L

Cargo Type Linear 9mer 3,5 difluorophenylglycine

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human THP-1 Monocyte-Like Cell Line

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Cargo Type 7-mer cyclic lactam

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

Evidence 3 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Human THP-1 Monocyte-Like Cell Line

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Linear L

Cargo Type Triazole

In Vitro or In Vivo In vitro

DSSP Secondary Structure CCCCCCCCC

DSSP_Secondary_Structure

CCCCCCCCC