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Peptide record

TPDB63137

CVP1 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB63137
CVP1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
MARRARRPRGRFYAFRRGR
Physicochemical Analysis
C104H174N46O21S1
NDCEQHILKSTWV
R
2436.88
12.94
9
0
7
+9
3.82
-1.647
15.79
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
61.14
1
Residue Composition
number
3
A
9
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
1
M
2
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 3 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 1 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
19
C104H174N46O21S1
2436.88
12.94
+9
3.82
-1.647
Free
L
Linear
Conjugated with FITC
N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

293T Cells, HCT-116 Cells, 3T3 Cells Or Mdck Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
β-galactosidase enzyme, plasmid and poly (I:C) and FITC dye
Specific green fluorescence dots could be clearly observed in HCT116, 293T, 3T3 and MDCK cells treated with CVP1, but not with Mut-CVP1 and FITC dye only. The mean per cent of relative internalization of CVP1 was 0.1, 2.1, 18.7, 86, 98% at 0.1, 1, 2, 5 and 10 μM, respectively.
Caveolae mediated endocytosis
In vitro
CCCSCCCC
Additional Detail Fields 1 fields
CCCSCCCC