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Peptide record

TPDB63137

CVP1 Cell-penetrating Peptides modified_plain modified
19 amino acids
Basic Information
3D PDB MODEL
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Standard-residue backbone model; source-recorded chemical modifications are not verified in these coordinates.

TPDB63137
CVP1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 19-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
MARRARRPRGRFYAFRRGR
Physicochemical Analysis

Sequence-only estimates are not provided for modified or non-standard source notation. Reported molecular properties, when available, are retained below with their source records.

Chemical Descriptors
19 reviewed residue count
Free Activity
L Activity
Linear Activity
Conjugated with FITC Activity
N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)O Activity
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

293T Cells, HCT-116 Cells, 3T3 Cells Or Mdck Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
β-galactosidase enzyme, plasmid and poly (I:C) and FITC dye
Specific green fluorescence dots could be clearly observed in HCT116, 293T, 3T3 and MDCK cells treated with CVP1, but not with Mut-CVP1 and FITC dye only. The mean per cent of relative internalization of CVP1 was 0.1, 2.1, 18.7, 86, 98% at 0.1, 1, 2, 5 and 10 μM, respectively.
Caveolae mediated endocytosis
In vitro
CCCSCCCC
Additional Detail Fields 1 fields
CCCSCCCC