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Peptide record

TPDB63134

CPPL Cell-penetrating Peptides standard
29 amino acids
Basic Information
3D PDB MODEL
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TPDB63134
CPPL
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 29-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
N-terminal: Conjugation with FITC
Sequence
MAPQRDTVGGRTTPPSWGPAKAQLRNSCA
Physicochemical Analysis
C128H209N43O40S2
EHIFY
AP
3054.45
11.23
4
1
8
+3
5.25
-0.828
37.24
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
180.07
9
Residue Composition
number
4
A
3
R
1
N
1
D
1
C
0
E
2
Q
3
G
0
H
0
I
1
L
1
K
1
M
0
F
4
P
2
S
3
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 1 C: 1 E: 0 Q: 2 G: 3 H: 0 I: 0 L: 1 K: 1 M: 1 F: 0 P: 4 S: 2 T: 3 W: 1 Y: 0 V: 1
Chemical Descriptors
29
C128H209N43O40S2
3054.45
11.23
+3
5.25
-0.828
L
Linear
Conjugation with FITC
N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HEK and HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
Cytoplasm
Showed a higher fluorescence intensity than FITC-R11 in HEK 293 and HeLa cells
In vitro
CCSBTTTBCSSSSSTTSCCGGGTTTCCCC
Additional Detail Fields 1 fields
CCSBTTTBCSSSSSTTSCCGGGTTTCCCC